Frequency Of Use Research Articles

A Survey of UV Filters Used in Sunscreen Cosmetics

The aim of this study was to determine the types of UV filters used in adult and children’s sunscreen products sold in Poland (part of the EU market) and their frequency of use. The INCI compositions of sunscreen products were collected and analyzed for the presence of UV filters. The study included 150 randomly selected preparations for adults (from 71 brands) and 50 for children (from 33 brands). The survey concerned the UV filters listed in Annex VI to Regulation (EC) No 1223/2009 of the European Parliament and Council of 30 November 2009 on cosmetic products. The most frequently used UV filters in the child sunscreens were triazine derivatives: bis-ethylhexyloxyphenol methoxyphenyl triazine (60.0%) and ethylhexyl triazone (52.0%), and ethylhexyl salicylate (46.0%), a derivative of salicylic acid. The most common in adult sunscreens were butyl methoxydibenzoylmethane (56.0%), a dibenzoylmethane derivative, followed by the salicylic acid derivative ethylhexyl salicylate (54.7%) and the triazine derivatives bis-ethylhexyloxyphenol methoxyphenyl triazine (54.7%) and ethylhexyl triazone (50.0%). Physical filters, including their nano and non-nano forms, were more popular in sunscreens for children, i.e., 50.0% (TiO2) and 22.0% (ZnO), than for adults: 21.3% (TiO2) and 6.7% (ZnO). For both adults and children, many cosmetic products contained four or five UV filters per preparation; however, the child preparations often used two UV filters. To summarize, the following UV filters dominate in photoprotectors for both adults and children: butyl methoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, ethylhexyl salicylate, and diethylamino hydroxybenzoyl hexyl benzoate.

Association of acetaminophen use with perinatal outcomes among pregnant women: a retrospective cohort study with propensity score matching

BackgroundAlthough acetaminophen is widely used in women during pregnancy, its safety has not been clearly stated. The study aimed to investigate the association between acetaminophen use and adverse pregnancy outcomes in pregnant women in China.MethodsWe conducted a retrospective cohort study by collecting data on pregnant women who delivered in the Beijing Obstetrics and Gynecology Hospital from January 2018 to September 2023. An acetaminophen use group and a control group were formed based on prenatal exposure to acetaminophen. The pregnancy outcomes that we focused on were stillbirth, miscarriage, preterm birth, APGAR score, birth weight, and congenital disabilities. Pregnant women exposed to acetaminophen were matched to unexposed in a 1:1 ratio with propensity score matching, using the greedy matching macro. SPSS software was used for statistical analysis. Multivariable logistics regression was used to assess the association between acetaminophen use during pregnancy and adverse pregnancy outcomes.ResultsA total of 41,440 pregnant women were included, of whom 501 were exposed to acetaminophen during pregnancy, and 40,939 were not exposed. After the propensity score matching, the acetaminophen use and control groups consisted of 501 pregnant women each. The primary analysis showed that acetaminophen exposure during pregnancy was associated with an increased risk of stillbirth (adjusted OR (aOR) = 2.29, 95% CI, 1.19–4.43), APGAR score < 7 at 1 min (aOR = 3.28, 95% CI, 1.73–6.21), APGAR score < 7 at 5 min (aOR = 3.54, 95% CI, 1.74–7.20), APGAR score < 7 at 10 min (aOR = 3.18, 95% CI, 1.58–6.41), and high birth weight (HBW) (aOR = 1.75, 95% CI, 1.05–2.92). Drug exposure during the first and second trimesters increased the odds of stillbirth, miscarriage, APGAR < 7, and the occurrence of at least one adverse pregnancy outcome. In addition, the frequency of drug use more than two times was associated with a higher risk of preterm birth and APGAR score < 7.ConclusionsExposure to acetaminophen during pregnancy was significantly associated with the occurrence of adverse pregnancy outcomes, particularly exposure in the first and second trimesters and frequency of use more than twice. It is suggested that acetaminophen should be prescribed with caution in pregnant women.

Connection Between Knowing and Doing? A Mixed Methods Exploration of Librarian Wellness Behaviors

ABSTRACT The authors examined the relationship between access to or use of health information resources by health sciences librarians (HSLs) and non-HSLs. We wanted to know if, compared to non-HSLs, increased access to and use of health information by HSLs was associated with more frequent performance of wellness behaviors. : A survey containing questions about access to health information resources, the use of health information resources, the frequency of the performance of wellness behaviors and barriers and facilitators to performing these behaviors was sent via e-mail to members of over 60 library organizations. A total of 1913 librarians responded to the survey. We found no difference between the HSLs and the non-HSLs by age or sex but HSLs were more likely to have master’s degrees or higher, work more hours, and to work in institutions that provide access to vaccines and/or wellness programs. HSLs have greater access to and use quality health information resources more often than do non-HSLs. Compared to non-HSLs, HSLs exercise more and eat more fruits and vegetables. Non-HSLs, however, are more likely to engage in regular spiritual activities. Barriers to performing wellness behaviors included lack of time, lack of motivation, fatigue, and chronic pain whereas facilitators included positive social support for wellness behaviors. Our data show that access to health information and frequency of use is correlated with the performance of wellness behaviors. While access to health information can work to nudge people to engage in healthy habits, information by itself is not enough.

The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies.

Cannabis may have beneficial anti-inflammatory effects in people with HIV (PWH); however, given this population's high burden of persisting neurocognitive impairment (NCI), clinicians are concerned they may be particularly vulnerable to the deleterious effects of cannabis on cognition. Here, we present a systematic scoping review of clinical and preclinical studies evaluating the effects of cannabinoid exposure on cognition in HIV. Results revealed little evidence to support a harmful impact of cannabis use on cognition in HIV, with few eligible preclinical data existing. Furthermore, the beneficial/harmful effects of cannabis use observed on cognition were function-dependent and confounded by several factors (e.g., age, frequency of use). Results are discussed alongside potential mechanisms of cannabis effects on cognition in HIV (e.g., anti-inflammatory), and considerations are outlined for screening PWH that may benefit from cannabis interventions. We further highlight the value of accelerating research discoveries in this area by utilizing translatable cross-species tasks to facilitate comparisons across human and animal work.

Systematic review of cognitive and behavioral strategies used in effective harm reduction interventions for people who use cocaine.

The aim of this systematic review is to identify cognitive and behavioral strategies that have been used in effective harm reduction interventions for people who use cocaine. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and the search was performed on February 26, 2023 across databases including PsycInfo, PubMed, Scopus, and Web of Science. Studies were included if they (1) report the use of one cognitive or behavioral strategy, (2) have harm reduction as the objective, (3) involve participants who used cocaine as at least one of their substances, (4) be published within the last 10 years, and (5) have a randomized controlled trial design. The Cochrane RoB 2.0 Tool was used to assess risk of bias. The cognitive and behavioral strategies were extracted and organized based on their frequency of use in the studies and their corresponding outcomes. The final synthesis included k = 10 studies with N = 3,567 participants. Psychoeducation strategies, influence on social norms, personalized feedback, increased self-efficacy and motivational interviewing were the most frequently used promising strategies across studies. This review underscores the significance of incorporating cognitive and behavioral strategies within harm reduction interventions, as they represent a promising domain that could enhance the effectiveness of addressing cocaine use.

Household energy behaviour in the times of crisis: Lessons for policy initiatives from peripheral, fossil-dependent regions of the European Union

Drawing on the survey research conducted on a representative sample of 1200 Polish households living in peripheral, fossil-dependent regions, this paper explores the hitherto unrecognised changes in energy behaviour in the residential sector, which resulted from the increase in energy prices that initiated in 2022 after the Russia's invasion on Ukraine. We consider only no-tech and low-tech sustainable energy practices that meet the needs of households and deliver lasting reductions in domestic energy use and the increase of their energy efficiency. We concentrate on final energy consumption, i.e. energy behaviour related to heating houses, washing oneself and washing dishes, washing and drying clothes, as well as using TV, computers, household appliances and home lighting. We analyse the frequency of use of low-tech and no-tech practices and indicate the socio-economic and demographic characteristics of households and home features that differentiate them. In addition, applying the method of association rules, we outline key traits of household exhibiting different types of energy behaviour, namely ‘avoid’, ‘shift’ and ‘improve’. We use this knowledge to formulate implications for policy initiatives at European, national and local levels aiming at increasing the inclusiveness of the energy transition process.

The Rise of Telemedicine in the Philippines during COVID-19: A Systematic Review of Utilization Trends and Patient Outcomes

The study discussed the telemedicine trends in the Philippines during the COVID-19 pandemic from 2019 to 2023. Determining the frequency of use of telemedicine, the factors that influenced its use before and during the COVID-19 pandemic, and the effects of telemedicine in improving the healthcare system in the Philippines. A systematic review was conducted using thematic analysis and the PRISMA checklist. The results presented a pattern indicating that teleconsultation usage corresponded to increased COVID-19 cases. Furthermore, telemedicine utilization surged from March 2020 to March 2022, with video consultations increasing from 5 to 495 monthly visits between 2019 and 2022. The study concluded that it was driven by increased mobile phone usage, improved patient satisfaction, government support, and increased video consultations, offering alternative healthcare delivery. Future studies should include more regions and timeframes to comprehensively present telemedicine trends in the Philippines.

Macro- and Microstructure Model of the Dictionary of Names of Own&#x0D; Electronic Resource «Armenian Text of Russian Poetry»

The article presents the characteristics of the structure of the dictionary of proper names, functioning in the studied local text, developed within the framework of the project «Electronic resource “Armenian text of Russian poetry”: representation of the local text of Russian literature». In the macrostructure of the dictionary, it is supposed to single out the «core», which includes onomastic units (mainly anthroponyms and toponyms) with high indices of frequency of use within the entire analyzed material, and a peripheral area of low-frequency names that form the so-called onomastic background. The microstructure of the dictionary&#x0D; will be made up of three vocabulary zones: subject information, language information and additional information. The subject area of a dictionary entry includes basic information about the bearer of the name and is built in accordance with the type and status of the heading unit. The elements of the language zone&#x0D; are the accentological, grammatical and derivational characteristics of the name and information about its etymology. The additional information zone contains links to all texts of the collected corpus in which the analyzed onomastic unit is&#x0D; found (the most significant texts, for example, where they are included in the title, can be given in the text of the dictionary entry), as well as information included in the associative and cultural background of the name (in case of its presence and explication). The volume and content of dictionary entries will be determined by the individual properties of the specific onym being described.

Prediction of the healing efficiency of episiotomy wounds using hydrogel dressings with lidocaine

The objective: to study the factors affecting the healing process of an episiotomy wound and the effectiveness of using hydrogel dressings with lidocaine for its healing.Materials and methods. The prospective randomized study includes the analysis of anamnestic data from the medical cards of 123 primiparous women with episiotomy wounds who gave birth in the Kyiv City Maternity Hospital No. 5 during 2021–2022. The women were divided into two groups: a comparison group – 63 patients who received standard treatment, and a research group – 60 patients who additionally used hydrogel dressings with lidocaine on the wound.The healing of episiotomy wounds was evaluated according to the REEDA scale. Factors that may influence episiotomy wound healing were studied in patients of both groups: anthropometric indicators (age, height, body mass index), interventions during childbirth, and indicators of obstetric and gynecological history (term of gestation, volume of blood loss during childbirth, body weight of the newborn, etc.). Statistical analysis was performed using the Fisher, Mann–Whitney, Student and chi-square tests of the statistical package EZR v. 1.54.Results. Age (p=0.689) and body mass index (p=0.974) of patients in both groups did not show statistically significant differences. The duration of the second period of labor on average was 72 min (57.6–86.4) in the comparison group versus 43.2 min (28.8–57.6) in the research group with a statistically significant difference (p&lt;0.001). No statistically significant differences were found between the two groups regarding the term of delivery, the volume of blood loss, the weight of the newborn, the risk of pregnancy loss, the frequency of labor induction, the weakness of labor activity, manual revision of the uterine cavity, and vacuum extraction of the fetus. The frequency of use of different types of anesthesia during childbirth also did not differ (р=0.396).REEDA scale assessment revealed a reduced risk of high sum scores in the research group (odds ratio (OR) = 0.16, 95% confidence interval (CI): 0.07–0.38), that supports the efficacy of hydrogel dressings with lidocaine. Analysis of the duration of the second labor period and gestational term also revealed an association with the risk of a high sum of points on the REEDA scale (OR = 1.22, 95% CI: 1.02–1.45 per 0.01 days; OR = 1.65, 95% CI: 1.16–2.35 per week of pregnancy).A multivariate model which included research group, body mass index, duration of the second labor period, gestational term confirmed a reduced risk according to the REEDA scale in this group (OR = 0.19, 95% CI: 0.08–0.47). The four-factor model had a high accuracy (AUC = 0.81, 95% CI: 0.73–0.88), indicating a strong relationship between the selected factors and the risk of complications after episiotomy.Conclusions. The use of hydrogel dressings with lidocaine and taking into account some aspects of childbirth, namely, the duration of childbirth and gestational period, can contribute to the improvement of the course of healing of episiotomy wounds. Such a comprehensive approach supports the effectiveness and significance of using hydrogel dressings with lidocaine in the practice of modern obstetrics to improve the results of treatment of patients with an episiotomy wound.In the future, studies on the effectiveness of using hydrogel dressings for the treatment of episiotomy wounds are necessary.

Changing the functioning of the article in the history of the German language

The subject of the study is the historical changes in the syntactic structure of the German language; the object of the study is articles. The authors consider in detail the use of definite, indefinite and null articles based on the material of a fragment of the Gospel of Luke, which were published in various periods of the German language: the text of Tatiana, translated by Martin Luther, made in 1545; an adapted version of Luther's translation, published in 2017 and a lightweight electronic version created as a result of deviation from the canonical translation. Particular attention is paid to the frequency of use of articles, the reasons for the increase or decrease in their use, as well as other means of determination. It is established that modern electronic text shows a tendency to decrease nominal groups, which, accordingly, leads to a decrease in articles. The tendency to decrease the zero article is manifested by the early Upper German period; in modern German, there is a displacement of the definite article.  The methodological basis is based on a systematic approach to the interpretation of the phenomena of linguistic ontology in diachrony. The research methods are comparative historical analysis, the method of distributive analysis, quantitative analysis, methods of N. Chomsky's theory of control and binding. The main conclusions of the proposed study are the revealed historical processes in the system of articles of the German language. It was found that at an early stage of language development, the zero article dominated in texts, which significantly narrowed the manifestation of determination. The main burden during this period fell on possessive nominal groups, which primarily included proper names. The definite article was used much less frequently. In nominal groups that are part of the prepositional group, the zero article was mainly used, which eventually led to the creation of stable prepositional constructions with a zero article. The largest number of all types of articles falls on Luther's translation adapted to the modern grammatical structure of the German language, which is associated with the maximum use of nominal groups. What is new is the establishment in modern German of a tendency to reduce the zero and definite articles.

Стратегия эффективного административного контроля антимикробной терапии в отделении реанимации и интенсивной терапии хирургического профиля: ретроспективное пилотное исследование.

Objective: To evaluate a strategy for effective administrative control of targeted antimicrobial therapy in surgical intensive care unit (ICU) patients. Materials and methods. The study included 3522 patients who were treated in ICU No. 1 in the period 2022 to 2023. The first group (control), treatment period 2022, included 1764 patients. The second group (research), treatment period 2023, included 1758 patients. In both groups, the use of antimicrobial drugs (AMP) was carried out in accordance with the antibacterial therapy control strategy (ASCT); in group 2, systemic administrative control was additionally carried out in the form of the use of the “Effective Hospital” program and a developed analytical system with monitoring the financial stability of the unit, aimed at daily monitoring of operating activities. A comparative analysis of the frequency of use of various classes of antimicrobial agents, the incidence of infectious complications, mortality rates and financial costs between groups was performed. Results. There was a significant decrease in the consumption of AMPs of the carbapenem group from 8194 vials in 2022 to 6577 vials in 2023, which was a decrease of 19.7%; a decrease in the consumption of tetracycline group AMPs in 2023 compared to 2022, from 2338 bottles to 1581 bottles, which amounted to 32.4%; reduction in the consumption of vancomycin and linezolid in 2023 compared to 2022 from 562 vials to 313 vials, which amounted to 44.3%. There was a decrease in the incidence of VAP from 59.3 (57.6; 62.9) in 2022 to 48.1 (38.65; 61.9) units in 2023, which amounted to 10.8% (p = 0.053). The increase in the frequency of deaths from 10.9% (9.1; 12.4) in 2022 to 11.5% (10.5; 12.7) in 2023 did not have significant differences (p = 0.67). The total expenditure on AMP in 2023 significantly decreased by 22.3%, which allowed saving 1,477,205.53 rubles (p = 0.012). Conclusion. The use of a daily strategy of administrative control of operational activities and the use of antimicrobial therapy in the ICU can reduce the costs of expensive antimicrobial agents, reduce the incidence of nosocomial infectious and inflammatory complications without changing overall mortality.

Comparative Analysis of Color Vocabulary in the Translations of W. Shakespeare's Sonnets 127–154

Khamit Yergaliyev is a poet who fully translated the sonnets of William Shakespeare into Kazakh. In his translation work, he turned to the Russian version of the sonnets translated by Samuil Marshak. The colors used by W. Shakespeare in his sonnets 127–154 are analyzed in this article. According to the usage of each color the excerpts from the poet’s sonnets were given, and their meaning and frequency were determined and shown in the study. The original excerpts are reviewed and compared with Samuil Marshak’s and Khamit Yergaliev’s variants. The purpose of this research is a detailed analysis of the use of colors in the sonnets of W. Shakespeare in all three of its versions. The article aims to reveal the differences and similarities between the variants, as well as the features of each writer. The idea of this scientific work is to compare the use of colors in all three versions, to identify the most frequently used color, to show the frequency of use of colors in the translated variants. The scientific significance of the presented work lies in the insufficient study of Kh. Yergaliev’s variant of the sonnets in this particular direction. The practical significance of the study is determined by the usefulness of the presented data for the research work of students, undergraduates and doctoral students. Methods of analysis and synthesis were widely used. Sorting method was effective for the systematization of the research. The basis was the comparative method, through which significant results were obtained. These methods allowed us to conclude that there are various differences in the use of colors between the original sonnets and versions by S. Marshak and Kh. Yergaliev. This article can become a guideline for future research on the analysis of translated versions of sonnets.

Inhibition of personal protective action against heat by gender stereotypes: A Japanese survey conducted in the summer of 2023

Exposure to extreme heat significantly affects human health and often causes death. Public health agencies encourage people to take preventive action against heat illness. Research on risk reduction behavior reveals that perceived effectiveness, self-efficacy, and risk perception motivate people to implement measures against various risks. This study empirically examines how gender stereotyping affects the use of umbrellas. Accordingly, Tokyo residents (N = 658) were surveyed on September 27 and 28, 2023, regarding their frequency of use of protective materials against heat during the summer of 2023. Results revealed that the survey participants associated the use of umbrellas more with women than with men. Hence, gender stereotype reduced the participants' use of umbrellas regardless of their gender. Self-efficacy had a stronger effect on umbrella use than any other explanatory variable. This study did not find evidence that perceived effectiveness, cost, and effort determine umbrella use. The findings imply that while creating messages to promote the adoption of preventive measures against extreme heat, they should consider how stereotypes affect people's willingness to adopt certain measures.

Uso y conocimiento tradicional de plantas medicinales en comunidades de Villa Corzo, Chiapas, México

The use and knowledge of native and naturalized medicinal plants were evaluated in four communities of Villa Corzo, Chiapas, Mexico. The information was obtained through semi-structured surveys conducted with 118 people of different age and gender categories. To determine the most important plant species, indexes of value and frequency of use were generated. Seventy-nine species of 49 families were recorded, as well as their use in the treatment of various diseases according to local knowledge. The species with the highest value of use were Aloe vera (L.) Burm. f., Verbena officinalis L. (verbena), Ocimum basilicum L. (basil) and Psidium guajava L. (guava). (guava). The most important families by number of species used were, in order of importance: Asteraceae and Rutaceae with five species Lamiaceae, Fabaceae and Rosaceae with four species each.

THE ONLINE DATING INTENSITY SCALE (ODI): VALIDITY AND RELIABILITY STUDY OF TURKISH FORM

The main purpose of the current research is to adapt the Online Dating Intensity Scale (CFAS), developed by Bloom and Taylor (2019) to evaluate the frequency of use of individuals using online dating programs, into Turkish and to conduct reliability and validity studies of the scale. The sample of the research consists of 110 participants who have previously used and/or are currently using any online dating program. Within the scope of the current study, the original form of the scale was translated into Turkish by experts, and the back-translation was made by experts fluent in both languages. For the validity and reliability analyses of the scale, Confirmatory Factor Analysis (CFA) was examined for construct validity, and Cronbach alpha internal consistency coefficient and Composite Reliability (CR) coefficients were examined for reliability analyses. Research findings revealed that the two-factor solution was confirmed in Confirmatory Factor Analysis (CFA). In addition, the Cronbach Alpha Coefficient of the scale is 0.92, and the Composite Reliability (CR) coefficients are 0.86 for the attitudes and 0.71 for intensity sub-dimensions. As a result, it was concluded that the scale has very good psychometric properties and allows a valid and reliable assessment of the intensity of online dating experiences in Turkish culture.

Questionnaire-Based Study of 392 Women in Abbottabad, Pakistan, to Evaluate the Types of Cosmetic Products Purchased Between December 2018 and March 2019 and Their Associated Adverse Events.

BACKGROUND Cosmetics are applied topically to enhance appearance and are commonly used by women of all ages. Cosmetics contain many chemical agents, but the incidence of adverse reactions is low, possibly due to underreporting. This questionnaire-based study included 392 women to evaluate information on the types of cosmetics purchased between December 2018 and March 2019, their use by the women surveyed, and their associated adverse events. MATERIAL AND METHODS A cross-sectional study was conducted among 392 women in Abbottabad, Pakistan, using a pre-structured and validated questionnaire to evaluate information on the types of cosmetics, their use, and their associated adverse events. Part 1 of the study collected information about demographics. Part 2 contained a total of 11 items, and collected the frequency of use of cosmetic on skin and hair care products. Part 3 consisted of 4 items and collected information about problems encountered due to the use of cosmetics. RESULTS In the winter season, 47.7% (n=187) of women preferred chemical-based cosmetic products, while 30.9% (n=121) preferred Ayurvedic products. Among commonly used cosmetic products, 26.9% (n=106) of women used foundations. The most frequently used skin care product was face wash 39.5% (n=155). The most prevalent adverse events related to cosmetics were pimples (19.9%, n=78), redness (17.6%, n=69), and eye discomfort (15.8%, n=62). Furthermore, 51.3% (n=201) strongly agreed that cosmetics aid in getting a whiter complexion. CONCLUSIONS The survey concluded that most women preferred cosmetics with a chemical base, which are associated with rashes, redness, and acne. It is important to encourage cosmetovigilance and awareness campaigns among cosmetic product sellers and users.

Virtual Reality Relaxation for Stress in Young Adults: A Remotely Delivered Pilot Study in Participants’ Homes

AbstractHigh stress levels experienced by young adults were exacerbated by COVID-19 and traditional stress management techniques can be challenging. Virtual reality (VR) relaxation appears promising and is accessible remotely; however, research on young adults is limited, especially in naturalistic settings. This remotely delivered and controlled mixed-methods study investigated feasibility and acceptability of VR relaxation for young adults (N = 23, mean age = 22.96) at home during the pandemic. VR participants (N = 11) were asked to complete daily VR relaxation sessions (scenes of virtual beaches, mountains, the sea, and more) for a 14-day intervention period, alongside visual analogue scales (VAS) of psychological well-being pre- and post-VR sessions. Post-intervention, VR participants completed semi-structured interviews. Control participants (N = 12) received no intervention. Both groups completed outcome measures of psychological well-being pre- and post-intervention periods to evaluate feasibility of remote data collection. VAS results indicated acceptability of daily VR, with significant short-term increases in relaxation, happiness, and connectedness to nature, and decreases in stress, anxiety, and sadness within VR participants. VR usage and 100% completion of outcome measures indicated feasibility of VR relaxation and remote data collection. Qualitative findings suggest participants found the VR relaxing, but interest diminished over time and technical issues hindered user experience. This suggests a more informal, less prescriptive frequency of VR use may be more appealing for young adults, although adherence may relate to technical issues. Greater interactivity and remote technical assistance within VR could increase engagement. Future research should investigate optimal frequency of use, longer-term impact, and technical issues with a larger sample.

Evidence-Based Recommendations for Education Provided to Patients and Families Regarding the Adverse Events of ALK and MEK Inhibitors: A Systematic Review From the Children's Oncology Group.

Background: Pediatric oncology patients receive multiple modalities of therapy to treat their malignancies. These modalities have the potential for acute toxicity and late effects. In the last decade, a new modality known as targeted biological therapy, has become an integral part of treatment for pediatric cancers. As targeted therapy use has increased, adverse events specific to these targeted agents have emerged, requiring a new effort focused on providing education to patients and families regarding how best to report, monitor, and manage these adverse events. Method: A clinical question was developed to guide the systematic literature review. Anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase kinase (MEK) inhibitors were selected for review due to their frequency of use in pediatric oncology. The search was conducted to identify relevant articles published between January 1, 2000 and May 5, 2020. Articles were screened by two team members for inclusion/exclusion criteria using the web-based systematic review tool, Rayyan. Results: Twenty-seven articles met the eligibility criteria for inclusion and were evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation criteria. Adverse events for ALK and MEK inhibitors included manifestations of the gastrointestinal, hematologic, dermatologic, musculoskeletal, neurological, cardiovascular, and ocular systems. Recommendations for patient/family education were made for ALK and MEK inhibitors based on the reported adverse events. Conclusions: Adverse events of ALK and MEK inhibitors differ from the more common adverse events experienced with conventional treatment modalities used in pediatric oncology. It is important for nurses to include information regarding potential adverse events in patient/family education for children receiving these targeted agents.

Structural and semantic analysis of the concept union in political media discourse (comparative study of the English, German and Russian languages)

The article analyzes the semantic structure of the concept  union by comparing its semantic markers for different European languages within the media discourse. The purpose of the article is to determine the features of individual meanings expressed through semantic markers in the media discourse of these languages and reflecting the uniqueness of the implementation of the concept union in semantic terms. When considering the features of meaning, semantic markers associated with the central concept are established; patterns of their frequency of use in the languages under study and factors influencing the transformation of semantics are determined. The interrelation of situations of communicative interaction and its influence on the realization of the specific meaning of the concept union indicate the high relevance of the study.The choice of linguistic means of implementing the concept and the role of the communicative situation in this process has a significant impact on the negative or positive assessment of the phenomenon itself. The research methodology includes elements of system analysis, linguistic description method, discourse analysis, semantic and component analysis. The study uses statistical data extracted from the corpus corresponding to the declared languages by automatic sampling according to the specified parameters.The authors conclude that the semantic structure of the concept is realized depending on the communicative situation by various semantic markers, which, with the similarity of structures in the course of historical development and various social experiences, have a divergence of meaning, which may later serve as a space for various kinds of semantic manipulations in modern media discourse. The peculiarities of the use of the concept union in politically oriented texts of the studied languages are also of interest.

Finite Complement Clauses in Disciplinary Research Articles Authored by Filipino Academic Writers

Finite complement clauses (FCCs) are an understudied syntactic structure of L2 advanced academic writing. The present study cross-investigated FCCs in qualitative (QUALI) and quantitative (QUANTI) research articles written by Filipino academic writers (FAWs) in Applied Linguistics (APPLING), Communication (COMM), and Measurement and Evaluation (MEEV). Specifically, it determined the FCCs with the most occurrences across five disciplinary research article sub-registers and identified whether these FCCs differ significantly in terms of frequencies of use. With Hernandez’s (2021) framework adapted from Biber and Gray’s (2016) study, this research analyzed five FCCs in 42 disciplinary research articles. Major results revealed that verb-controlled that-clauses (with 33.69 as normalized frequency count) outnumbered other FCCs in research article sub-registers across disciplines. They were more recurrent in QUALI and QUANTI APPLING research articles (7.91 and 7.54, respectively) and QUANTI and QUALI COMM research articles (7.34 and 6.96, respectively) than in QUANTI MEEV research articles (3.94). In addition, a significant difference exists between them and other FCCs at the p&lt;.05 level in terms of frequencies of use. In view of these findings, it can be concluded that verb-controlled that-clauses are the most useful FCCs in APPLING, COMM, and MEEV research articles. Likewise, FAWs across the three disciplines write more informally as signposted by their repeated use of that complementizer with these FCCs controlled by verbs. The study draws its implications for academic writing instruction.